Role of Insulin in Endogenous Hypertriglyceridemia*
Why the study?
Does insulin response correlate with the degree of hypertriglyceridemia induced by a high carbohydrate diet?
Population
33 patients studied for dietary carbohydrate accentuation of endogenous triglyceride production
Design
Cohort
Follow-up
3 weeks
Authors
Discussion
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Implication
Insulin response correlates with carbohydrate-induced hypertriglyceridemia; hypothesis-generating and requires prospective validation before clinical application.
Key Points
- This study aims to explore how insulin affects triglyceride levels in patients on a high carbohydrate diet.
- Evaluated 33 patients on a high carbohydrate (fat-free) liquid formula diet for 3 weeks.
- Measured plasma triglyceride concentrations and insulin responses.
- Correlated triglyceride levels with insulin response post-diet.
- 31 of 33 patients exhibited a spectrum of plasma triglyceride concentrations.
- Two patients had triglyceride levels exceeding 2000 mg/100 ml with removal defects.
- Hypertriglyceridemia correlated highly with insulin response (P < 0.005).
Structured PICO
Does insulin response correlate with the degree of hypertriglyceridemia induced by a high carbohydrate diet?
P
Population
33 patients studied for dietary carbohydrate accentuation of endogenous triglyceride production
I
Intervention
High carbohydrate (fat-free) liquid formula diet for 3 weeks
O
Outcome
Steady-state plasma triglyceride concentrations and their correlation with insulin responsesurrogate
Carbohydrate-induced hypertriglyceridemia is highly correlated with postprandial insulin response, suggesting it results from an increase in hepatic triglyceride secretion driven by insulin.
Cite This Study
Reaven et al. (1967) studied this question.