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November 1, 1969Diabetes

Immunoreactive Insulin, Glucose Tolerance, and Carbohydrate Inducibility in Types II, III, IV, and V Hyperlipoproteinemia

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Why the study?

Does plasma insulin level determine the degree of carbohydrate-induced hypertriglyceridemia in patients with different types of hyperlipoproteinemia?

Population

Normal subjects and patients with Types II, III, IV, and V hyperlipoproteinemia

Comparison

High carbohydrate diet (carbohydrate induction) vs Normal subjects

Design

Cross-sectional

Authors

CGCharles J. GlueckGeneral / Preventive / LipidsRLRobert I. LevyGeneral / Preventive / LipidsDFDonald S. FredricksonGeneral / Preventive / Lipids

Discussion

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Implication

Does not support insulin as primary driver of carbohydrate-induced hypertriglyceridemia; leaves open other determinants in hyperlipoproteinemia.

Key Points

  • To examine the relationship between carbohydrate-induced triglyceride elevation, glucose tolerance, and insulin secretion across distinct types of hyperlipoproteinemia.
  • Measured plasma triglyceride responses (ΔTG) following high-carbohydrate feeding in normal subjects and individuals with Types II, III, IV, and V hyperlipoproteinemia.
  • Correlated carbohydrate inducibility with glucose tolerance, insulinogenic indices, basal triglyceride concentrations, and ponderal index across all participant groups.
  • Carbohydrate inducibility (ΔTG) was similar to controls in Type II, consistently elevated in Type III, highly variable in Type IV, and widely scattered in Type V patients.
  • Abnormal glucose tolerance occurred in approximately one-third of Types II and III, half of Type IV, and 80% of Type V patients, with hyperinsulinemia predominating in Type V.
  • Insulin output and insulinogenic indices correlated positively with ΔTG in healthy controls, but no significant correlation occurred in any hyperlipoproteinemic group.

Structured PICO

Does plasma insulin level determine the degree of carbohydrate-induced hypertriglyceridemia in patients with different types of hyperlipoproteinemia?

P
Population
Normal subjects and patients with Types II, III, IV, and V hyperlipoproteinemia
I
Intervention
High carbohydrate diet (carbohydrate induction)
C
Comparator
Normal subjects
O
Outcome
Carbohydrate inducibility (change in triglycerides, ΔTG)surrogate

Plasma insulin levels are not the primary determinant of carbohydrate-induced hypertriglyceridemia in patients with hyperlipoproteinemia.

Cite This Study

Glueck et al. (1969) studied this question.

synapsesocial.com/papers/6a86d5b5ed1c9801b3cf85dfhttps://doi.org/10.2337/diab.18.11.739
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Conversion of Type III Hyperlipoproteinaemia to Type IV Hyperlipoproteinaemia by a Fat‐Free, Carbohydrate Rich Diet1975 · 10 citations
  2. 2Very low density lipoprotein triglyceride transport in type IV hyperlipoproteinemia and the effects of carbohydrate-rich diets1970 · 195 citations
  3. 3The Kinetics of Plasma Free Fatty Acid and Triglyceride Transport in Patients with Idiopathic Hypertriglyceridaemia and Their Relation to Carbohydrate Metabolism1974 · 34 citations
  4. 4Insulin resistance, glucose intolerance, and hyperinsulinemia. Hypertriglyceridemia versus hypercholesterolemia.1993 · 89 citations
  5. 5The Kinetics of Plasma Free Fatty Acid and Triglyceride Transport in Patients with Idiopathic Hypertriglyceridaemia and Their Relation to Carbohydrate Metabolism1974 · 43 citations