What question did this study set out to answer?

To unify dispersed protein-chemical interaction data and integrate contextual features including quantitative binding affinities and tissue-specific expression patterns.

November 20, 2015Nucleic Acids ResearchOpen Access

STITCH 5: augmenting protein–chemical interaction networks with tissue and affinity data

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Authors

DSDamian SzklarczykSIB Swiss Institute of Bioinformatics ASAlberto SantosNovo Nordisk Foundation CMChristian von MeringSIB Swiss Institute of Bioinformatics

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Implication

Database development integrates binding affinity and tissue-specific expression for 430,000 chemicals, highlighting refined contextual mapping of molecular interactions.

Key Points

To unify dispersed protein-chemical interaction data and integrate contextual features including quantitative binding affinities and tissue-specific expression patterns.
Aggregated protein-chemical interaction evidence across multiple databases, literature text mining, and computational prediction methods for 430,000 chemicals.
Integrated chemical binding affinities directly into network visualizations and incorporated spatial expression filters to isolate interactions occurring within specific tissues.
Provided user access through full database downloads, an extensive application programming interface (API), and a redesigned web interface.
Expanded the repository scope to cover integrated interaction evidence for 430,000 chemical compounds across multiple organismal networks.
Implemented dynamic filtering of global networks to restrict interaction partners to those co-expressed in user-selected anatomical tissues.

Cite This Study

Szklarczyk et al. (2015) studied this question.

synapsesocial.com/papers/69cd0447a8a7ac4456558b98 https://doi.org/10.1093/nar/gkv1277

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Implication

Database development integrates binding affinity and tissue-specific expression for 430,000 chemicals, highlighting refined contextual mapping of molecular interactions.

STITCH 5: augmenting protein–chemical interaction networks with tissue and affinity data

Discussion

Member takes

Implication

Key Points

Cite This Study

STITCH 5: augmenting protein–chemical interaction networks with tissue and affinity data

Discussion

Member takes

Implication

Key Points

Cite This Study

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