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April 1, 2026Russian Journal of Bioorganic Chemistry

Novel Pyrrole-Based Thiazole Conjugates: Design, Synthesis, Antioxidant, Antidiabetic Assessment, Molecular Docking, Simulation, and In Silico ADME Studies

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Authors

BSBhawana SatiBanasthali UniversityASAnuradha SharmaBanasthali UniversityADAakash DeepChaudhary Devi Lal University

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Implication

Novel pyrrole-thiazole compounds show strong antioxidant and antidiabetic effects, suggesting potential for drug development.

Key Points

  • The study aims to synthesize novel pyrrole-thiazole conjugates for potential antidiabetic applications.
  • Synthesized pyrrole-thiazole analogues by reacting thiosemicarbazide with substituted formyl pyrrole.
  • Carried out molecular docking and in silico ADME studies to evaluate drug-like properties.
  • Assessed antioxidant activity through IC50 values and evaluated α-amylase inhibitory effects.
  • Compound A11 demonstrated the best antioxidant activity with an IC50 value of 15.28 μg/mL.
  • Compounds A9 and A11 showed strong α-amylase inhibition with IC50 values of 2.10 and 12.10 μg/mL, respectively.
  • A9 and A11 significantly reduced blood glucose levels, indicating effective antidiabetic properties.

Cite This Study

Sati et al. (2026) studied this question.

synapsesocial.com/papers/69cd7a095652765b073a6d68https://doi.org/10.1134/s1068162025604033
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