What question did this study set out to answer?

To synthesize and characterize a novel series of thiazole derivatives bearing a benzodioxole scaffold and evaluate their antioxidant, anticholinesterase, and antidiabetic potential.

September 17, 2026PharmaceuticalsOpen Access

Synthesis, Characterization, Biological Evaluation and In Silico Studies of Some New Thiazole Derivatives

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Authors

TCTugce Caklili YSYusuf Sıcak SCSomdatta Y. Chaudhari

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Overview

In vitro study demonstrates potent antioxidant, antidiabetic, and anticholinesterase activities in novel thiazole derivatives, indicating therapeutic potential for neurodegenerative and metabolic...

Key Points

To synthesize and characterize a novel series of thiazole derivatives bearing a benzodioxole scaffold and evaluate their antioxidant, anticholinesterase, and antidiabetic potential.
Synthesized nine thiazole-benzodioxole derivatives (compounds 1–9) and confirmed their structures.
Assessed in vitro antioxidant capacity using ABTS and DPPH assays, and measured enzyme inhibition against AChE, BChE, α-amylase, and α-glucosidase.
Conducted molecular docking, molecular dynamics simulations, and in silico ADMET pharmacokinetic predictions.
Compounds 8 (4-trifluoromethyl) and 9 (phenyl) exhibited the strongest ABTS and DPPH radical scavenging activities, driven by efficient hydrogen atom transfer and extended π-conjugation.
Compounds 3 (4-SO2CH3) and 5 (3,4-diCl) bearing electron-withdrawing groups demonstrated superior dual inhibition of AChE/BChE and α-amylase/α-glucosidase, outperforming the reference antidiabetic drug acarbose.

Cite This Study

Caklili et al. (2026) studied this question.

synapsesocial.com/papers/6aabb6725f706d05830e4e35 https://doi.org/10.3390/ph19091468

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September 17, 2026PharmaceuticalsOpen Access

Synthesis, Characterization, Biological Evaluation and In Silico Studies of Some New Thiazole Derivatives

View Full Paper

Ask AI

Bookmark

Authors

TCTugce Caklili YSYusuf Sıcak SCSomdatta Y. Chaudhari

Discussion

Member takes

Overview

In vitro study demonstrates potent antioxidant, antidiabetic, and anticholinesterase activities in novel thiazole derivatives, indicating therapeutic potential for neurodegenerative and metabolic...

Key Points

To synthesize and characterize a novel series of thiazole derivatives bearing a benzodioxole scaffold and evaluate their antioxidant, anticholinesterase, and antidiabetic potential.
Synthesized nine thiazole-benzodioxole derivatives (compounds 1–9) and confirmed their structures.
Assessed in vitro antioxidant capacity using ABTS and DPPH assays, and measured enzyme inhibition against AChE, BChE, α-amylase, and α-glucosidase.
Conducted molecular docking, molecular dynamics simulations, and in silico ADMET pharmacokinetic predictions.
Compounds 8 (4-trifluoromethyl) and 9 (phenyl) exhibited the strongest ABTS and DPPH radical scavenging activities, driven by efficient hydrogen atom transfer and extended π-conjugation.
Compounds 3 (4-SO2CH3) and 5 (3,4-diCl) bearing electron-withdrawing groups demonstrated superior dual inhibition of AChE/BChE and α-amylase/α-glucosidase, outperforming the reference antidiabetic drug acarbose.

Cite This Study

Caklili et al. (2026) studied this question.

synapsesocial.com/papers/6aabb6725f706d05830e4e35 https://doi.org/10.3390/ph19091468

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