What question did this study set out to answer?

The project aims to explore the geographical distribution, resistance patterns, and gene mutations of ESBL-producing bacteria in Africa.

April 1, 2026Wellcome Open ResearchOpen Access

Distribution of extended spectrum beta-lactamase antibiotic resistance in Africa 2005-2021

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Authors

MPMiriam PuschelKilimanjaro Christian Medical Centre BMBrian L. MatembaKilimanjaro Christian Medical Centre HKHappiness D. KajokaFaculty of Public Health

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Implication

Analysis reports geographical distribution and resistance patterns of ESBL-producing organisms in selected African countries, indicating critical areas for intervention.

Key Points

The project aims to explore the geographical distribution, resistance patterns, and gene mutations of ESBL-producing bacteria in Africa.
Data obtained from the Pfizer-ATLAS Antibiotic Resistance Database from 2005-2021
Categorized variables like age, sample type, and year of isolation
Utilized WHO AWaRe classification for assessing resistance
Conducted descriptive statistics and geospatial analysis using R v.4.4.3
Majority of ESBL-producing isolates were from South Africa and Nigeria
K. pneumoniae was predominant (55.5%), especially in pediatric (78.4%) and respiratory (82.5%) samples
Resistance to ampicillin was over 99%, with higher resistance seen in K. pneumoniae against several antibiotics
Nigerian and Moroccan isolates showed the highest resistance levels
The CTXM1 gene was present in 90.8% of isolates, with Egypt and Cameroon having the highest resistance gene burden per isolate.

Cite This Study

Puschel et al. (2026) studied this question.

synapsesocial.com/papers/69cd7a4e5652765b073a7539 https://doi.org/10.12688/wellcomeopenres.24137.1

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Implication

Analysis reports geographical distribution and resistance patterns of ESBL-producing organisms in selected African countries, indicating critical areas for intervention.

Distribution of extended spectrum beta-lactamase antibiotic resistance in Africa 2005-2021

Discussion

Member takes

Implication

Key Points

Cite This Study

Distribution of extended spectrum beta-lactamase antibiotic resistance in Africa 2005-2021

Discussion

Member takes

Implication

Key Points

Cite This Study

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