Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
April 1, 2026Open Access

Ablation of the Ccr2 gene exacerbates polyarthritis in interleukin-1 receptor antagonist-deficient mice

View Full Paper
Ask AI
Bookmark
Share

Authors

HFHiroshi FUJIITBTomohisa BabaYIYuko IshidaKanazawa University

Discussion

Loading...

Member takes

Implication

Demonstrates exacerbated arthritis in Il1rn-deficient mice following Ccr2 gene ablation, suggesting regulatory roles of neutrophils.

Key Points

  • The study aims to investigate the role of the CCR2 chemokine receptor in the development of rheumatoid arthritis in Il1rn-deficient mice.
  • Assessed clinical arthritis signs in Il1rn and Il1rn-Ccr2 double-deficient mice.
  • Performed histologic examination to evaluate joint conditions.
  • Measured bone mineral density using computed tomography.
  • Identified infiltrating cells via immunohistochemical and flow cytometric analysis.
  • Inhibited neutrophil accumulation using anti-CXCR2 antibody.
  • Ablation of Ccr2 worsened arthritis and increased osteoclastogenesis in Il1rn-deficient mice.
  • Enhanced neutrophil accumulation was observed, while macrophage levels remained unchanged.
  • Infiltrated neutrophils showed increased expression of RANKL and ADAM-8, promoting osteoclastogenesis.
  • Double-deficient mice exhibited elevated levels of neutrophilic chemokines compared to Il1rn-deficient mice.
  • Neutralizing CXCR2 antibodies significantly reduced arthritis severity in double-deficient mice.

Cite This Study

FUJII et al. (2011) studied this question.

synapsesocial.com/papers/69cd7a4e5652765b073a75c7https://doi.org/10.24517/00027537
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Development of Chronic Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Interleukin 1 Receptor Antagonist–Deficient Mice2000 · 761 citations
  2. 2Defects in Macrophage Recruitment and Host Defense in Mice Lacking the CCR2 Chemokine Receptor1997 · 729 citations
  3. 3The CCR2 receptor as a therapeutic target2005 · 65 citations
  4. 4CCL2 in Rheumatoid Arthritis: A Context-Dependent Cross-Cellular Node Serving as Biomarker and Therapeutic Target2026
  5. 5Selective accumulation of CCR5+ T lymphocytes into inflamed joints of rheumatoid arthritis1999 · 142 citations