What question did this study set out to answer?

To determine the in vivo pathophysiological role of interleukin-1 receptor antagonist (IL-1ra) in immune regulation and joint disease using gene-targeted mouse models on different genetic backgrounds.

January 17, 2000The Journal of Experimental MedicineOpen Access

Development of Chronic Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Interleukin 1 Receptor Antagonist–Deficient Mice

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Authors

RHReiko HoraiNational Institutes of Health SSShinobu SaijoChiba University HTHidetoshi TaniokaKyoto Prefectural University of Medicine

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Implication

Murine knockout study demonstrates spontaneous rheumatoid-like polyarthropathy and autoimmunity in IL-1ra-deficient mice, indicating IL-1ra is vital for immune homeostasis.

Key Points

To determine the in vivo pathophysiological role of interleukin-1 receptor antagonist (IL-1ra) in immune regulation and joint disease using gene-targeted mouse models on different genetic backgrounds.
Generated IL-1ra-deficient mice via gene targeting on both BALB/cA and C57BL/6J genetic backgrounds.
Evaluated joint histopathology for synovial inflammation and articular erosion.
Measured serum autoantibody titers against immunoglobulins, type II collagen, and double-stranded DNA, and quantified joint proinflammatory cytokine expression.
Spontaneous chronic inflammatory polyarthropathy developed in 100% of IL-1ra-deficient BALB/cA mice, whereas C57BL/6J mice remained disease-free.
Histopathology revealed marked synovial inflammation and granulation tissue invasion closely resembling human rheumatoid arthritis.
Deficient BALB/cA mice developed high autoantibody titers and significant overexpression of proinflammatory cytokines (IL-1beta, IL-6, and TNF-alpha) in affected joints.

Cite This Study

Horai et al. (2000) studied this question.

synapsesocial.com/papers/6a145ca3f88db7183c59fcab https://doi.org/10.1084/jem.191.2.313

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Implication

Murine knockout study demonstrates spontaneous rheumatoid-like polyarthropathy and autoimmunity in IL-1ra-deficient mice, indicating IL-1ra is vital for immune homeostasis.

Development of Chronic Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Interleukin 1 Receptor Antagonist–Deficient Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Development of Chronic Inflammatory Arthropathy Resembling Rheumatoid Arthritis in Interleukin 1 Receptor Antagonist–Deficient Mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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