Key result
IL-1Ra-deficient mice showed increased aortic valve leaflet thickness compared to wild-type mice at 12 weeks of age (P<0.001), a process mediated by T-cell derived TNF-alpha.
p-value: p=<0.001
IL-1Ra deficiency induces aortic valve inflammation and stenosis in mice, a process that is importantly mediated by TNF-alpha.
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Animal findings implicate IL-1Ra in valve thickening; leaves open any role in human aortic stenosis.
Isoda et al. (2010) studied Aortic valve stenosis. IL-1Ra deficiency vs. Wild-type mice was evaluated on Aortic valve leaflet thickness (p=<0.001). IL-1Ra-deficient mice showed increased aortic valve leaflet thickness compared to wild-type mice at 12 weeks of age (P<0.001), a process mediated by T-cell derived TNF-alpha.
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