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To investigate the clinical association of regulatory B cells in patients with systemic sclerosis (SSc).

April 1, 2026Open Access

Decreased levels of regulatory B cells in patients with systemic sclerosis: Association with autoantibody production and disease activity

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To investigate the clinical association of regulatory B cells in patients with systemic sclerosis (SSc).
Measured blood IL-10 producing Breg cell levels using FACS in SSc patients and healthy controls.
Analyzed Breg cell levels in six individual dcSSc patients before and after treatment.
Breg cell levels were significantly lower in SSc patients compared to healthy controls (P<0.0001).
Decreased Breg cells were linked with higher levels of anti-topo I and anticentromere antibodies.
Breg cell levels in dcSSc patients increased after treatment, which correlated with decreased disease activity (P<0.05).

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Findings reveal decreased regulatory B cells in systemic sclerosis, indicating a link to disease activity and autoantibody production.

松下 et al. (2015) studied this question.

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