Lewis Acid-Promoted Annulation of Electron-Deficient Indoles toward Indoloindoles and Higher Fused Architectures

Sreejith K. Aravindakshan; Muhammad  Sibil M P; Jayalakshmi Achath; Sunil Varughese; Jomon Mathew; Jubi John

doi:10.1039/d6cc01297c

January 1, 2026Chemical Communications

Lewis Acid-Promoted Annulation of Electron-Deficient Indoles toward Indoloindoles and Higher Fused Architectures

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Key Points

The objective is to develop a Lewis acid-catalyzed method for synthesizing indole-fused heteroacenes from electrophilic reagents.
Utilized Lewis acid catalysis for heteroannulation.
Combined electrophilic indoles and anilines as reactants.
Conducted DFT studies to analyze reaction mechanisms.
The method shows a broad substrate scope.
Demonstrated scalability for practical applications.
Indicated successful formation of indole-fused compounds.

Implication

This research demonstrates a method for synthesizing indole-fused heteroacenes using Lewis acids, indicating a versatile approach.

Abstract

Herein, we report a Lewis acid–catalyzed heteroannulation strategy for the synthesis of indole-fused heteroacenes from electrophilic indoles and anilines. The method exhibits broad substrate scope and scalability. DFT studies reveal...

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Cite This Study

Aravindakshan et al. (2026) studied this question.

synapsesocial.com/papers/69cd7ae65652765b073a8635 https://doi.org/10.1039/d6cc01297c

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Lewis Acid-Promoted Annulation of Electron-Deficient Indoles toward Indoloindoles and Higher Fused Architectures

Key Points

Implication

Abstract

Discussion

Cite This Study

Lewis Acid-Promoted Annulation of Electron-Deficient Indoles toward Indoloindoles and Higher Fused Architectures

Key Points

Implication

Abstract

Discussion

Cite This Study

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