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This research aims to explore the relationship between gastric emptying and the postprandial insulin and glucose responses during the 75-g OGTT.

April 1, 2026Open Access

Influence of Gastric Emptying on the Outcome of the 75-g Oral Glucose Tolerance Test

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Findings indicate gastric emptying affects insulin and glucose responses in diabetic individuals, suggesting implications for diabetes diagnosis.

This research aims to explore the relationship between gastric emptying and the postprandial insulin and glucose responses during the 75-g OGTT.
Recruitment of 82 diabetic patients without medication
Assessment of gastric emptying using the 13C-acetate breath test
Administration of 75 g glucose after an overnight fast
Collection of breath samples at 10-minute intervals for 180 minutes
Positive correlation observed between serum insulin at 30 min and 13CO2 excretion at 30, 60, and 90 minutes
Inverse correlation found between serum glucose and 13CO2 excretion
Homeostasis model assessment for insulin resistance showed limited correlation with 13CO2 excretion except at 90 min

Suzuki et al. (2020) studied this question.

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Findings indicate gastric emptying affects insulin and glucose responses in diabetic individuals, suggesting implications for diabetes diagnosis.