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April 1, 2026Archives of ToxicologyOpen Access

High-throughput PBK modelling for dermal exposure: a pragmatic approach to predict systemic pharmacokinetics

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Authors

ZEZeynep EdizcanSSStephan SchallerLKLars Kuepfer

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Overview

This research demonstrates effective systemic pharmacokinetics predictions in chemical risk assessment, utilizing non-animal data approaches.

Key Points

  • The aim is to model systemic pharmacokinetics for dermal exposure using high-throughput physiologically based kinetic modelling.
  • Applied HT-PBK modelling to simulate systemic pharmacokinetics profiles of 52 chemicals.
  • Used skin permeation model from Open Systems Pharmacology Suite.
  • Compared various QSAR tools for parameters like lipophilicity and solubility for model parameter optimization.
  • The best HT-PBK approach predicted 73% of Cmax and 75% of AUC values within a tenfold range of observed data.
  • Predicted systemic pharmacokinetics showed a tendency toward overprediction, particularly for dermal exposure compared to oral.
  • Key exposure metrics were reproduced within acceptable limits, indicating model feasibility for risk assessment.

Cite This Study

Edizcan et al. (2026) studied this question.

synapsesocial.com/papers/69cd7b475652765b073a9314https://doi.org/10.1007/s00204-026-04357-4
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