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June 29, 2026Archives of ToxicologyOpen Access

PBK modelling of phthalates and their metabolites and the application in next generation risk assessment

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Authors

MSMiaoying ShiAPAns PuntGPGopal Pawar

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Overview

Randomized trial demonstrates risk assessment for phthalates in next generation methodologies, highlighting metabolite impact.

Key Points

  • The study aims to enhance next generation risk assessment (NGRA) by modeling the bioactive metabolites of phthalates.
  • Developed PBK models for dibutyl phthalate (DBP), di(2-ethylhexyl) phthalate (DEHP), and their metabolites
  • Used in silico and in vitro data for metabolic clearance
  • Predicted plasma maximum concentrations (Cmax) and calculated bioactivity-exposure ratios (BERs)
  • PBK models predicted plasma kinetics within a 2-fold difference for metabolites
  • Predicted Cmax values for parent compounds were lower than minimal points of departure, yielding BERs higher than 20,000
  • Consideration of metabolites significantly reduced BERs, with a lowest value of 8.1, emphasizing their role.

Cite This Study

Shi et al. (2026) studied this question.

synapsesocial.com/papers/6a420b2ff91bb43ea919241bhttps://doi.org/10.1007/s00204-026-04487-9
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