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The research aims to compare the urinary excretion of monochlorobenzene metabolites in rats and humans.

April 1, 2026Open Access

Differences in urinary monochlorobenzene metabolites between rats and humans.

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Reveals differences in urinary excretion of monochlorobenzene metabolites in rats and humans, suggesting implications for exposure assessment.

The research aims to compare the urinary excretion of monochlorobenzene metabolites in rats and humans.
Administered monochlorobenzene to rats and humans via intraperitoneal, oral, or inhalation methods.
Measured urinary levels of p-chlorophenylmercapturic acid and 4-chlorocatechol after hydrolysis.
Compared metabolite excretion levels between rats and humans.
Rats excreted more p-chlorophenylmercapturic acid than 4-chlorocatechol after administration.
Humans excreted significantly less p-chlorophenylmercapturic acid compared to 4-chlorocatechol.
4-chlorocatechol conjugate was identified as a suitable index for monitoring exposure in humans.

Ogata et al. (1982) studied this question.

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Reveals differences in urinary excretion of monochlorobenzene metabolites in rats and humans, suggesting implications for exposure assessment.