Does intense exercise induce an ARVC-like phenotype without desmosomal gene mutations in endurance athletes with complex ventricular arrhythmias?
Intense exercise may induce an ARVC-like phenotype without an identifiable genetic predisposition in endurance athletes.
In this athletic cohort, we found lower than expected rates of desmosomal gene mutations, particularly among those performing the most exercise. This adds further weight to the hypothesis that an ARVC-like phenotype may be acquired through intense exercise without an identifiable genetic predisposition.
Gerche et al. (2010) studied this question.