Key result
Exercising below the AHA recommended minimum was associated with a lower risk of meeting ARVC diagnostic criteria or experiencing sustained ventricular arrhythmias (adjusted OR 0.03; 95% CI 0.003-0.26).
Why the study?
While exercise restriction is recommended for ARVC patients because exercise worsens disease course, exercise recommendations for genotype-positive family members remained incompletely resolved.
Does exercise restriction prevent disease manifestation and sustained ventricular arrhythmias in genotype-positive family members of ARVC patients?
Cohort (n=101)
Does exercise restriction prevent disease manifestation and sustained ventricular arrhythmias in genotype-positive family members of ARVC patients?
Odds Ratio: 0.03 (95% CI 0.003–0.26)
Exercise restriction below the AHA recommended minimum is highly protective against disease penetrance and ventricular arrhythmias in genotype-positive ARVC family members, with exercise playing a potentially greater role in promoting disease in females.
No takes yet. Share an insight, caveat, or question.
Exercise restriction may lower arrhythmic risk in genotype-positive ARVC relatives; leaves open need for prospective trials before changing practice.
Wang et al. (2020) conducted a cohort in Arrhythmogenic right ventricular cardiomyopathy (ARVC) (n=101). Exercising below the AHA recommended minimum (650 MET-hours/year) vs. Exceeding the AHA recommended minimum was evaluated on Diagnosis by 2010 Task Force Criteria or development of sustained ventricular arrhythmias (adjusted OR 0.03, 95% CI 0.003-0.26). Exercising below the AHA recommended minimum was associated with a lower risk of meeting ARVC diagnostic criteria or experiencing sustained ventricular arrhythmias (adjusted OR 0.03; 95% CI 0.003-0.26).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: