April 25, 2020EP Europace
Helping patients to help themselves: informing individuals predisposed to arrhythmogenic cardiomyopathy
Why the study?
Does exercise restriction prevent the development of overt ARVC in genotype-positive family members?
Population
Genotype-positive family members of arrhythmogenic right ventricular cardiomyopathy patients
Comparison
Exercise restriction to <150 min of mild to… vs Exercise above 150 min of mild to moderate…
Design
Editorial
Authors
Discussion
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Member takes
Implication
Restricting exercise to less than 150 minutes of mild-to-moderate activity per week may significantly reduce the penetrance of ARVC in genotype-positive family members.
Structured PICO
Does exercise restriction prevent the development of overt ARVC in genotype-positive family members?
P
Population
Genotype-positive family members of arrhythmogenic right ventricular cardiomyopathy (ARVC) patients (excluding probands)
I
Intervention
Exercise restriction to <150 min of mild to moderate exercise per week
C
Comparator
Exercise above 150 min of mild to moderate exercise per week
O
Outcome
Development of overt ARVC
Restricting exercise to less than 150 minutes of mild-to-moderate activity per week may significantly reduce the penetrance of ARVC in genotype-positive family members.
Limitations
- Use of retrospective questionnaires is prone to recall bias
- Regression to the mean in self-reported exercise levels
Cite This Study
Gerche et al. (2020) studied this question.