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January 28, 2014BioinformaticsOpen Access

Minfi: a flexible and comprehensive Bioconductor package for the analysis of Infinium DNA methylation microarrays

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Authors

MAMartin J. AryeeBroad InstituteAJAndrew E. JaffeJohns Hopkins UniversityHBHéctor Corrada BravoGenesys (United States)

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Implication

Software demonstration reveals comprehensive analysis pipelines for Infinium DNA methylation microarrays, highlighting flexible computational workflows for large-scale epigenomic studies.

Key Points

  • Introduce Minfi, a specialized computational software package within the Bioconductor environment for analyzing high-throughput Infinium DNA methylation microarrays.
  • Engineered an open-source software framework within the R/Bioconductor ecosystem tailored to process Infinium array data.
  • Integrated modular workflows encompassing raw intensity extraction, quality control, data preprocessing, and signal normalization.
  • Delivers a comprehensive software platform supporting end-to-end analysis of Infinium DNA methylation arrays.
  • Facilitates identification of differentially methylated positions and regions across diverse biological and clinical conditions.

Cite This Study

Aryee et al. (2014) studied this question.

synapsesocial.com/papers/69cecbdb978f5f183732aeedhttps://doi.org/10.1093/bioinformatics/btu049
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