What question did this study set out to answer?

To determine whether blood pressure serves as an independent risk factor for the development of end-stage renal disease in men and women.

April 22, 2003Hypertension

Blood Pressure Predicts Risk of Developing End-Stage Renal Disease in Men and Women

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Why the study?

Does high blood pressure increase the risk of developing end-stage renal disease in men and women?

Population

Men and women, 20 to 98 years of age, screened in Okinawa, Japan

Comparison

High-normal blood pressure and hypertension vs Optimal blood pressure

Design

Cohort

Follow-up

1983 through 2000 (17 years)

Authors

MTMasahiko TozawaThird Way KIKunitoshi IsekiTotal (France)CIChiho IsekiThe Nakamura Hajime Eastern Institute

Discussion

Member takes

Implication

High-normal BP and hypertension were associated with ESRD risk in both sexes; extends observational data but leaves causality and intervention effects open.

Key Points

To determine whether blood pressure serves as an independent risk factor for the development of end-stage renal disease in men and women.
Screened 98,759 individuals (46,881 men and 51,878 women aged 20 to 98 years) in 1983 in Okinawa, Japan.
Tracked incident end-stage renal disease from 1983 through 2000 by linking screening records with a regional dialysis registry.
Calculated relative risk adjusted for age and body mass index across categories of systolic and diastolic blood pressure.
Over the 17-year follow-up, 400 participants developed end-stage renal disease, comprising 231 men and 169 women.
High-normal blood pressure and hypertension were associated with statistically significant increases in the relative risk of end-stage renal disease compared with optimal blood pressure in both men and women.

Structured PICO

Does high blood pressure increase the risk of developing end-stage renal disease in men and women?

Population

Men and women, 20 to 98 years of age, screened in Okinawa, Japan

Intervention

High-normal blood pressure and hypertension (exposure)

Comparator

Optimal blood pressure

Outcome

Development of end-stage renal disease (ESRD)hard clinical

High-normal blood pressure and hypertension are significant risk factors for the development of end-stage renal disease in both men and women, emphasizing the need for blood pressure control.

Cite This Study

Tozawa et al. (2003) studied this question.

synapsesocial.com/papers/69cf2d8f381d67a1d0ab6a09 https://doi.org/10.1161/01.hyp.0000069699.92349.8c

Topics

Hypertension management

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Implication

High-normal BP and hypertension were associated with ESRD risk in both sexes; extends observational data but leaves causality and intervention effects open.

Blood Pressure Predicts Risk of Developing End-Stage Renal Disease in Men and Women

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Blood Pressure Predicts Risk of Developing End-Stage Renal Disease in Men and Women

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider