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April 3, 2026Materials Today BioOpen Access

Dual-Functional Hydrogel Platform Suppresses M1 Activation and Stabilizes M2 Macrophages in Intervertebral Disc Degeneration

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Authors

YXYiwen XuZZZijun ZhangZCZhenzhong Chen

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Overview

This approach enhances tissue repair in intervertebral disc degeneration, suggesting novel therapeutic strategies.

Key Points

  • The research aims to develop a hydrogel platform that simultaneously suppresses M1 macrophage activation and stabilizes M2 macrophages to improve tissue regeneration.
  • Developed a hydrogel that interacts with reactive oxygen species to control macrophage behavior.
  • Used poly-L-lactic acid scaffold for localized electrical stimulation.
  • Tested the hydrogel in a rat model of puncture-induced intervertebral disc degeneration.
  • The hydrogel platform effectively reduced M1-driven inflammation.
  • Enhanced stabilization of M2 macrophages was observed.
  • Improved disc repair outcomes were noted in the animal model.

Cite This Study

Xu et al. (2026) studied this question.

synapsesocial.com/papers/69cf58cb5a333a8214609a78https://doi.org/10.1016/j.mtbio.2026.103087
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Hybrid membrane nanovesicles reprogram macrophages to resolve oxidative stress in intervertebral disc degeneration2026
  2. 2Immune-defensive microspheres promote regeneration of the nucleus pulposus by targeted entrapment of the inflammatory cascade during intervertebral disc degeneration2024 · 15 citations
  3. 3Nanozyme-integrated hydrogel orchestrates mitochondrial quality control to counter inflammatory and oxidative milieu during disc degeneration.2026
  4. 4Pathology‐Responsive Self‐Assembling Hydrogel Enabling Spatiotemporally Controlled Exosome Release and Redox Regulation for Intervertebral Disc Regeneration2026
  5. 5Synergistic microenvironment therapy: a dual-function nanogel of supramolecular collagen ll-mimetic matrix and antioxidant MXene for attenuating intervertebral disc degeneration2026