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February 21, 2026Journal of NanobiotechnologyOpen Access

Synergistic microenvironment therapy: a dual-function nanogel of supramolecular collagen ll-mimetic matrix and antioxidant MXene for attenuating intervertebral disc degeneration

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Authors

GLGan LyuZGZhan GaoZCZ. Alexander Cao

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Overview

Microenvironment therapy demonstrates improved tissue repair and reduced oxidative stress in IVDD.

Key Points

  • The study aims to develop a therapeutic strategy that addresses both oxidative stress and tissue repair in intervertebral disc degeneration.
  • Utilized a dual-function nanogel combining Mo₂C MXene and a collagen II-mimetic matrix.
  • Examined effects of the nanogel on nucleus pulposus cells' oxidative stress and cellular functions.
  • Tested the nanogel in a rat model of intervertebral disc degeneration.
  • The nanogel significantly reduced oxidative stress and preserved mitochondrial function.
  • It improved nucleus pulposus cell adhesion and promoted new extracellular matrix synthesis.
  • The treatment restored disc height, hydration, and overall ECM architecture in the rat model.

Cite This Study

Lyu et al. (2026) studied this question.

synapsesocial.com/papers/69994c14873532290d02047ahttps://doi.org/10.1186/s12951-026-04211-w
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pathology‐Responsive Self‐Assembling Hydrogel Enabling Spatiotemporally Controlled Exosome Release and Redox Regulation for Intervertebral Disc Regeneration2026
  2. 2Pathological microenvironment-responsive nano-glycospheres restore disc homeostasis by combinatorial metabolic and genetic regulation2026
  3. 3Hybrid membrane nanovesicles reprogram macrophages to resolve oxidative stress in intervertebral disc degeneration2026
  4. 4The MnO2/GelMA Composite Hydrogels Improve the ROS Microenvironment of Annulus Fibrosus Cells by Promoting the Antioxidant and Autophagy through the SIRT1/NRF2 Pathway2024 · 13 citations
  5. 5Chondroitin Sulfate Reinforces Mitochondrial Redox Homeostasis to Enable Integrated Intervertebral Disc Regeneration2026