Randomized trial demonstrates chondroitin sulfate improves disc regeneration in rat model, suggesting effective therapy for IVDD.
Key Points
The aim is to investigate the dual therapeutic role of chondroitin sulfate in enhancing disc regeneration and addressing oxidative stress in intervertebral disc degeneration.
Utilized an injectable PVA/collagen/chondroitin sulfate hydrogel for targeted delivery and mechanical support.
Evaluated its effects in a rat model of intervertebral disc degeneration.
Measured disc architecture preservation, height restoration, and upregulation of antioxidant and matrix markers.
The hydrogel preserved disc architecture and restored disc height (specific metrics not provided).
Key antioxidant markers and matrix components were significantly upregulated after treatment.
Demonstrated coordinated repair of both the annulus fibrosus and nucleus pulposus.