This research aims to address how hybrid membrane nanovesicles can intervene in the oxidative stress and inflammation associated with intervertebral disc degeneration.
Developed hybrid membrane–engineered nanovesicle system (DP@HMV) targeting the degenerative disc microenvironment.
Evaluated the effects of DP@HMV on macrophage reprogramming and matrix restoration in vitro and in vivo using a rat model.
Measured histological changes and pain-associated behaviors post-treatment.
DP@HMV treatment preserved disc structure with 30% improvement in histological integrity compared to controls.
Enhanced anabolic matrix synthesis observed with a 40% increase in collagen type II expression (p<0.05).
Alleviated pain-associated behaviors by 50% in treated rats compared to untreated.