What question did this study set out to answer?

This research aims to compare the perioperative outcomes of remimazolam and sevoflurane in adult patients undergoing general anesthesia.

April 3, 2026BMC AnesthesiologyOpen Access

Remimazolam-based total intravenous vs. sevoflurane-based balanced general anesthesia on perioperative outcomes in adult surgical patients: a systematic review and meta-analysis

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Systematic review compares remimazolam and sevoflurane on perioperative outcomes in adults, suggesting hemodynamic benefits of remimazolam.

This research aims to compare the perioperative outcomes of remimazolam and sevoflurane in adult patients undergoing general anesthesia.
Conducted a systematic review and meta-analysis
Searched databases like PubMed and EMBASE for randomized controlled trials and observational studies
Analyzed primary and secondary outcomes using random-effects model statistics
Remimazolam maintained higher intraoperative mean arterial pressure and heart rate compared to sevoflurane
Lower vasopressor use was noted with remimazolam
Remimazolam significantly reduced postoperative nausea and vomiting while not affecting postoperative delirium
Eye-opening time was shorter for patients receiving remimazolam

Guerguer et al. (2026) studied this question.

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Systematic review compares remimazolam and sevoflurane on perioperative outcomes in adults, suggesting hemodynamic benefits of remimazolam.