What question did this study set out to answer?

The aim was to evaluate clozapine's effectiveness and safety for severe irritability in youth with autism spectrum disorder.

Clozapine for Severe Irritability in Children and Adolescents With Autism Spectrum Disorder

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Retrospective analysis shows clozapine reduces severe irritability in youth with autism, suggesting a promising treatment alternative.

The aim was to evaluate clozapine's effectiveness and safety for severe irritability in youth with autism spectrum disorder.
Retrospective case series of 13 patients under 18 years with ASD treated with clozapine.
Clinical outcomes assessed through Clinical Global Impression (CGI) scales.
Data on emergency visits, hospitalizations, and adverse events were documented.
Mean age of participants at clozapine initiation was 12.6 years.
8 out of 13 patients were classified as treatment responders based on CGI ratings.
Most common adverse events included sialorrhea, sedation, and increased appetite.

Sungur et al. (2026) studied this question.

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