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Proof-of-concept study evaluates cellular uptake of radiopharmaceutical surrogates in single cells, revealing intercellular variability.
The sensitivity of CyTOF enabled discrimination of uptake between cell models even at low metal-to-antibody stoichiometric ratios. It also revealed intercellular variability in uptake that can only be captured with single-cell methods. Overall, we showed that CyTOF is a robust, high-throughput, multiplexed approach for characterizing the cellular uptake of stable radiopharmaceutical surrogates at single-cell resolution, paving the way for future studies.
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Gómez-Sánchez et al. (2026) studied this question.
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