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April 3, 2026Journal of Cutaneous PathologyOpen Access

Multiplexed Immunofluorescent Characterization of T ‐Cell and Myeloid Cell Populations Reveals Histologic Subtype Differences Within the Immunosuppressive Landscape of Human Basal Cell Carcinoma

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Authors

ASAlan S. ShenCleveland Clinic Lerner College of MedicineLHLauren E. HeusinkveldHarvard UniversityAZAjay Zalavadia

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Overview

Multiplexed immunofluorescence reveals immune profile differences in infiltrative and non-infiltrative basal cell carcinoma, suggesting distinct behaviors.

Key Points

  • The aim is to identify differences in T cell and myeloid cell populations within human basal cell carcinoma tissues.
  • Utilized multiplexed immunofluorescence for characterization of cell populations.
  • Examined fixed formalin-fixed paraffin-embedded (FFPE) skin tumor tissues.
  • Analyzed T cell and myeloid cell profiles to identify differences.
  • Infiltrative basal cell carcinoma showed a more immunosuppressed landscape than non-infiltrative forms.
  • Distinct T cell and myeloid profiles were observed among histologic subtypes.

Cite This Study

Shen et al. (2026) studied this question.

synapsesocial.com/papers/69cf5e015a333a821460c0dbhttps://doi.org/10.1111/cup.70098
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Depicting the Immunological Landscape of Basal Cell Carcinoma Subtypes2026
  2. 2Tumor-Infiltrating T Cells in Skin Basal Cell Carcinomas and Squamous Cell Carcinomas: Global Th1 Preponderance with Th17 Enrichment—A Cross-Sectional Study2024 · 3 citations
  3. 3Clinical and Dermoscopic Characterization of Mixed-Type Basal Cell Carcinoma2026
  4. 4Tumor Infiltrating Lymphocytes in Cutaneous Squamous Cell Carcinoma—A Systematic Review2026
  5. 5<i>COL10A1</i> expression distinguishes a subset of cancer-associated fibroblasts present in the stroma of high-risk basal cell carcinoma2024 · 4 citations