In vitro analysis shows enhanced replication stress in cancer cells with nitro-substituted ruthenium complexes and ATR inhibitors, indicating potential new therapies.
Ruthenium(II) polypyridyl complexes (RPCs) are promising anticancer candidates owing to their ability to intercalate DNA and disrupt DNA replication. Here, we report a series of nitro-substituted ruthenium(II) complexes of the...
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Gan et al. (2026) studied this question.
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