Ruthenium( ii ) polypyridyl complexes and the DNA damage response: mechanisms and therapeutic implications

Martin R. Gill

doi:10.1039/d6md00154h

January 1, 2026RSC Medicinal ChemistryOpen Access

Ruthenium( ii ) polypyridyl complexes and the DNA damage response: mechanisms and therapeutic implications

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Key Points

This review aims to explore the mechanisms by which ruthenium(II) polypyridyl complexes activate DNA damage response pathways and influence cancer cell outcomes.
Summarizes the design and properties of ruthenium(II) polypyridyl complexes as DNA-targeting agents.
Links binding modes of complexes to the activation of DNA damage response pathways.
Discusses implications for cancer therapy based on these mechanisms.
Identifies specific pathways involved in the DNA damage response activated by ruthenium(II) complexes.
Describes potential therapeutic implications for targeting cancer cells using these agents.

Implication

Review summarizes ruthenium(II) complex design effects on DNA response in cancer cells, suggesting therapeutic potentials.

Abstract

This review summarises the design of ruthenium( ii ) polypyridyl complexes (RPCs) as pharmacological DNA-targeting agents, linking binding mode, DDR pathway activation, and cancer cell fate.

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Cite This Study

Martin R. Gill (2026) studied this question.

synapsesocial.com/papers/69fd7e23bfa21ec5bbf06509 https://doi.org/10.1039/d6md00154h

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Ruthenium( ii ) polypyridyl complexes and the DNA damage response: mechanisms and therapeutic implications

Key Points

Implication

Abstract

Discussion

Cite This Study

Ruthenium( ii ) polypyridyl complexes and the DNA damage response: mechanisms and therapeutic implications

Key Points

Implication

Abstract

Discussion

Cite This Study

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