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April 3, 2026BIOPHYSICS0 citations

Accumulation of Nitric Oxide Stabilized Forms in Rat Organs as a Result of Dinitrosyl Iron Complexes with N-Acetyl-L-Cysteine Ligand Administration

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ATA. A. TimoshinVLV. L. LakomkinAAA. A. Abramov

Key Points

  • This research aims to investigate how dinitrosyl iron complexes with N-acetyl-L-cysteine affect nitric oxide accumulation in rat organs.
  • Used the EPR method to analyze nitric oxide levels.
  • Administered dinitrosyl iron complexes sublingually to rats.
  • Assessed accumulation in various organs, including brain, heart, lungs, and liver.
  • Nitric oxide accumulation was observed in brain tissue of rats.
  • The effect in the brain was comparable to that in the heart, lungs, and liver.
  • Similar levels of nitric oxide stabilization were noted across different organs.

Abstract

The EPR method revealed that as a result of sublingual administration of dinitrosyl iron complexes with the ligand N-acetyl-L-cysteine in rats the transfer and accumulation of stable forms of nitric oxide (NO) occurs in brain tissue. The magnitude of this effect was found to be similar to that observed in the heart, lungs, and liver of the animals.

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Cite This Study

Timoshin et al. (2025) studied this question.

synapsesocial.com/papers/69cf5ea85a333a821460d247https://doi.org/10.1134/s0006350925701118
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