Population
Rat thoracic aortic rings and whole thoracic aortae
Comparison
Incubation with lipopolysaccharide 10 micrograms… vs Control, LPS without L-arginine, or LPS with…
Design
Preclinical
Authors
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No clinical translation warranted; leaves open whether dinitrosyl-iron complexes mediate NO effects in human vessels.
This preclinical study demonstrates that nitric oxide generated by LPS-induced NOS activity can be stored as protein-bound dinitrosyl-iron complexes in vascular tissue and released by N-acetylcysteine to induce relaxation.
Müller et al. (1996) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: