Key result
In rat aortas exposed to LPS, the adventitia contained the major part of NOS-2 protein and generated the largest amount of NO, impacting smooth muscle function.
Population
Rat aortas
Design
Preclinical
Follow-up
5 h and 20 h
Authors
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Adventitial NO overproduction may contribute to septic vasoplegia in models; leaves open translation to human inflammatory vascular disease.
The adventitia is a major source of NO triggered by LPS in the rat aorta, which impacts smooth muscle function and may be implicated in inflammatory diseases.
Kleschyov et al. (2000) studied Endotoxin exposure. Bacterial lipopolysaccharide (LPS) was evaluated on Nitric oxide (NO) overproduction and NOS-2 protein expression. In rat aortas exposed to LPS, the adventitia contained the major part of NOS-2 protein and generated the largest amount of NO, impacting smooth muscle function.
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