Population
Male Sprague-Dawley or Wistar rats
Comparison
Bacterial lipopolysaccharide vs Sterile saline injection
Design
Preclinical
Follow-up
up to 24 hours
Authors
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Does not support iNOS-mediated hyporesponsiveness in this sepsis model; leaves open mechanisms of splanchnic hypoperfusion for further study.
LPS induces NOS in the rat mesentery without causing hyporesponsiveness to vasoconstrictors, which may explain poor splanchnic perfusion during sepsis.
Mitchell et al. (1993) studied this question.
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