Key result
Acute (4 h) Escherichia coli endotoxemia significantly inhibited vasodilator responses to endothelium-dependent agonists (ACh and ADP) but not to nitroprusside in guinea pig aortas.
Population
Aortic vascular smooth muscle isolated from guinea pigs
Comparison
Induction of Escherichia coli endotoxemia for 4… vs Injection of saline (controls)
Design
Preclinical
Follow-up
4 hours
Authors
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May contribute to vasoplegia in Gram-negative sepsis; hypothesis-generating for human studies and should not yet change practice.
Acute endotoxemia inhibits the function of the constitutive isoform of nitric oxide synthase in vascular endothelial cells, which may lead to diminished vasodilator reserves during Gram-negative sepsis.
Parker et al. (1994) studied Escherichia coli endotoxemia. Escherichia coli endotoxemia (LPS) vs. Saline (controls) was evaluated on Vasodilator responses to endothelium-dependent and independent agonists. Acute (4 h) Escherichia coli endotoxemia significantly inhibited vasodilator responses to endothelium-dependent agonists (ACh and ADP) but not to nitroprusside in guinea pig aortas.
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