Why the study?
Does selective iNOS inhibition prevent hypotension in septic rats while preserving endothelium-dependent vasodilation?
Population
Rats exposed to lipopolysaccharide (LPS) for 6 h to induce sepsis
Comparison
Selective iNOS-inhibitor L-N6--lysine vs Nonselective NOS-inhibitor NG-nitro-l-arginine…
Design
Preclinical
Follow-up
6 hours
Authors
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Hypothesis-generating for selective iNOS inhibition in sepsis; leaves open translation to human vasodilatory shock trials.
Does selective iNOS inhibition prevent hypotension in septic rats while preserving endothelium-dependent vasodilation?
Selective iNOS inhibition prevents hypotension and metabolic derangements in a rat model of sepsis without impairing endothelium-dependent vasodilation, unlike nonselective NOS inhibition.
Strunk et al. (2001) studied this question.