Population
Rats administered lipopolysaccharide (LPS) to induce a sepsis-like state
Comparison
Specific iNOS inhibitors (-N6-lysine [L-NIL] and… vs LPS administration without NOS inhibitors
Design
Preclinical
Authors
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Selective iNOS inhibition may preserve GFR in septic models; leaves open translation to human AKI trials.
Selective iNOS inhibition prevents LPS-induced reductions in GFR, suggesting that renal dysfunction in sepsis is partly due to local inhibition of eNOS by iNOS.
Schwartz et al. (1997) studied this question.
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