December 9, 1991FEBS LettersOpen Access

The potent vasodilating and guanylyl cyclase activating dinitrosyl‐iron(II) complex is stored in a protein‐bound form in vascular tissue and is released by thiols

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Population

Purified soluble guanylyl cyclase and endothelium-denuded rabbit femoral artery and aortic segments

Design

Preclinical

Authors

AMAlexander MülschGoethe University Frankfurt PMPeter I. MordvintcevGoethe University Frankfurt АВА. Ф. ВанинSemenov Institute of Chemical Physics

Discussion

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Implication

Suggests a thiol-dependent vascular NO reservoir; leaves open its relevance to human endothelial function or disease.

Structured PICO

Population

Purified soluble guanylyl cyclase and endothelium-denuded rabbit femoral artery and aortic segments

Intervention

Dinitrosyl-iron(II)-L-cysteine (0.036-3.6 mM) and perfusion with N-acetyl-L-cysteine

Outcome

Activation of soluble guanylyl cyclase, vasodilation, and formation/release of dinitrosyl-iron(II) complex with protein thiolssurrogate

Nitric oxide can be stabilized and stored in vascular tissue as a dinitrosyl-iron(II) complex with protein thiols, which can be released by intra- and extracellular thiols to induce vasodilation.

Cite This Study

Mülsch et al. (1991) studied this question.

synapsesocial.com/papers/6a7e6507deca64d61c3c3e06 https://doi.org/10.1016/0014-5793(91)81441-a

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The potent vasodilating and guanylyl cyclase activating dinitrosyl‐iron(II) complex is stored in a protein‐bound form in vascular tissue and is released by thiols

Discussion

Member takes

Implication

Structured PICO

Cite This Study

The potent vasodilating and guanylyl cyclase activating dinitrosyl‐iron(II) complex is stored in a protein‐bound form in vascular tissue and is released by thiols

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider