Key result
Overweight post-CABG predicts ~92% higher odds of reduced NO levels and adverse echocardiographic changes.
Why the study?
Overweight and obesity increase risk for adverse outcomes post-CABG, with endothelial dysfunction and reduced nitric oxide bioavailability suspected as key mechanisms.
Does overweight status worsen echocardiographic parameters and nitric oxide levels in post-CABG patients during cardiac rehabilitation?
Cohort (n=155)
No
Does overweight status worsen echocardiographic parameters and nitric oxide levels in post-CABG patients during cardiac rehabilitation?
Answers are grounded in this paper and cite their sources.
In post-CABG patients, being overweight is associated with increased epicardial fat thickness, reduced nitric oxide levels, and impaired myocardial diastolic function, highlighting the need for targeted metabolic management during cardiac rehabilitation.
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Seitekova et al. (2026) conducted a cohort in Coronary Artery Disease post-Coronary Artery Bypass Grafting (n=155). Overweight (BMI ≥ 25 kg/m²) vs. Normal weight (BMI 18.5-24.9 kg/m²) was evaluated on Combined adverse changes in NO levels and echocardiographic parameters (OR 1.917, 95% CI 1.204-3.052, p=0.006). Overweight in post-CABG patients independently predicted reduced nitric oxide levels and adverse echocardiographic changes (OR 1.917).
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