Regioselective direct synthesis of mono-and bis -substituted benzimidazoles via base-switchable aerobic N-heterocyclic carbene organocatalysis

Key Points

• The research aims to develop a metal-free method for the regioselective synthesis of benzimidazole derivatives using N-heterocyclic carbene catalysts.
• Utilized a metal-free organocatalyst based on N-heterocyclic carbene.
• Optimized reaction conditions for regioselective synthesis.
• Synthesized mono- and bis-substituted benzimidazoles.
• Achieved high efficiency in the synthesis of benzimidazole derivatives.
• Successfully synthesized various mono- and bis-substituted compounds under optimal conditions.
• Demonstrated sustainability in the catalytic process.