Regioselective direct synthesis of mono-and bis -substituted benzimidazoles via base-switchable aerobic N-heterocyclic carbene organocatalysis

Janmejaya Sen; Richa Sharma; Amol Mahajan; Abdul Rahaman T A; Samir T. Sahu; Alexander S. Novikov; Sandeep Chaudhary

doi:10.1039/d6cy00036c

January 1, 2026Catalysis Science & Technology

Regioselective direct synthesis of mono-and bis -substituted benzimidazoles via base-switchable aerobic N-heterocyclic carbene organocatalysis

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Key Points

The research aims to develop a metal-free method for the regioselective synthesis of benzimidazole derivatives using N-heterocyclic carbene catalysts.
Utilized a metal-free organocatalyst based on N-heterocyclic carbene.
Optimized reaction conditions for regioselective synthesis.
Synthesized mono- and bis-substituted benzimidazoles.
Achieved high efficiency in the synthesis of benzimidazole derivatives.
Successfully synthesized various mono- and bis-substituted compounds under optimal conditions.
Demonstrated sustainability in the catalytic process.

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Implication

Demonstrates regioselective synthesis of benzimidazole derivatives, suggesting a sustainable, efficient approach for synthesizing valuable compounds.

Abstract

Herein, we disclosed a metal-free, highly efficient, and sustainable N-heterocyclic carbene-based organocatalyst utilized for the regioselective synthesis of mono -( 4a-o ) and bis -substituted benzimidazole ( 3a-s ) derivatives under the optimized reaction conditions. The...

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Sen et al. (2026) studied this question.

synapsesocial.com/papers/69cf5ea85a333a821460d3d6 https://doi.org/10.1039/d6cy00036c

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Regioselective direct synthesis of mono-and bis -substituted benzimidazoles via base-switchable aerobic N-heterocyclic carbene organocatalysis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

Regioselective direct synthesis of mono-and bis -substituted benzimidazoles via base-switchable aerobic N-heterocyclic carbene organocatalysis

Key Points

Ask about this paper

Implication

Abstract

Discussion

Cite This Study

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