What question did this study set out to answer?

Examine how hematological metrics influence cognitive decline through functional brain connectivity in children with beta-thalassemia major.

April 3, 2026Brain and Behavior0 citationsOpen Access

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Brain Functional Connectivity as a Mediator Between Hematological Metrics and Cognitive Decline in Children With Beta‐thalassemia Major

SXShumin XuShenzhen Children's Hospital YZYang ZhengXidian University YLYaowen LiShenzhen Children's Hospital

Key Points

Examine how hematological metrics influence cognitive decline through functional brain connectivity in children with beta-thalassemia major.
Analyzed hematological metrics in children with beta-thalassemia major.
Assessed cognitive performance through appropriate testing methods.
Explored functional connectivity signatures using connectivity pattern mapping (CPM).
Identified a negative correlation between hematological abnormalities and cognitive performance.
Found that functional connectivity disruptions are associated with cognitive vulnerability.
Suggested that functional connectivity signatures could serve as early neuromarkers.

Abstract

This study provides evidence that hematological abnormalities in β-TM children impair cognitive performance via their impact on functional brain networks. Functional connectivity signatures derived from CPM may serve as early neuromarkers of cognitive vulnerability and could inform future monitoring and intervention strategies in this population.

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Cite This Study

Xu et al. (Tue,) studied this question.

synapsesocial.com/papers/69cf5ecb5a333a821460d770 https://doi.org/https://doi.org/10.1002/brb3.71363

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