Altered Functional Brain Activity and Connectivity in Children with β-Thalassemia: A Resting-State fMRI Study

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Children with β-thalassemia exhibit reduced ALFF in key brain areas, impairing cognitive function.
Significant changes were observed in connectivity between the right posterior parietal cortex and anterior cerebellum.
Resting-state fMRI data was collected from 49 β-thalassemia children and 45 healthy controls for comparison.
Dysfunction in critical brain regions may inform new interventions for cognitive impairments in β-thalassemia.

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Resting-state fMRI reveals altered functional brain activity and connectivity in children with β-thalassemia, indicating possible cognitive deficits.

Zheng et al. (2025) studied this question.

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Resting-state fMRI reveals altered functional brain activity and connectivity in children with β-thalassemia, indicating possible cognitive deficits.