What question did this study set out to answer?

To assess alterations in functional connectivity in children and adolescents with β-thalassemia major and its relationship to cognitive impairment.

March 30, 2026Annals of HematologyOpen Access

Aberrant functional connectivity and Granger causality analysis in patients with β-thalassemia major

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To assess alterations in functional connectivity in children and adolescents with β-thalassemia major and its relationship to cognitive impairment.
Prospective study of 70 patients with β-thalassemia major and 64 healthy controls.
Cognitive function assessed using Montreal Cognitive Assessment and Modified Mini-Mental State Examination.
Region of interest-to-region of interest connectivity analysis for brain functional connectivity investigation.
Granger causality analysis utilized to evaluate effective interactions among network changes.
Patients displayed significant cognitive impairment compared to healthy controls.
Alterations in functional connectivity correlating with cognitive deficits were observed.
No correlation found between hematological parameters and cognitive function.

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Implication

Prospective study identifies cognitive impairment related to functional connectivity changes in children with β-thalassemia major, implying neuroimaging's potential role in assessment.

Cite This Study

Zheng et al. (2026) studied this question.

synapsesocial.com/papers/69c9c5a4f8fdd13afe0bd959 https://doi.org/10.1007/s00277-026-06893-6

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Implication

Prospective study identifies cognitive impairment related to functional connectivity changes in children with β-thalassemia major, implying neuroimaging's potential role in assessment.

Aberrant functional connectivity and Granger causality analysis in patients with β-thalassemia major

Key Points

Discussion

Implication

Cite This Study

Aberrant functional connectivity and Granger causality analysis in patients with β-thalassemia major

Key Points

Discussion

Implication

Cite This Study

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