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This research aims to clarify the role of body mass index (BMI) in survival outcomes after hepatic resection in hepatocellular carcinoma (HCC).

April 3, 2026CancersOpen Access

The Obesity Paradox in Hepatocellular Carcinoma: Insights from Continuous and Interaction-Based Analyses of Body Mass Index After Hepatic Resection

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This research aims to clarify the role of body mass index (BMI) in survival outcomes after hepatic resection in hepatocellular carcinoma (HCC).
Retrospective analysis of 1349 HCC patients post-hepatic resection
BMI assessed categorically and continuously
Survival analyzed using Kaplan–Meier and multivariable Cox proportional hazards models
Interaction terms examined across tumor-related subgroups
Overall survival (OS) significantly differed across BMI categories (p < 0.001)
3-year OS rates were 88%, 82%, and 62% for high, normal, and low BMI groups, respectively
Higher continuous BMI was associated with improved OS (hazard ratio 0.87, p = 0.005)
No significant association found between BMI and recurrence-free survival (RFS)

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This retrospective analysis examines BMI's impact on survival in HCC patients, suggesting host factors may explain obesity's paradox.

Lee et al. (2026) studied this question.

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