Population
Advanced HF patients with and without RVF, adult murine models, and neonatal rat ventricular myocytes
Comparison
Advanced HF with RVF vs without RVF, RV- vs LV-failure mouse models, and Wipi1 silencing vs control
Design
Integrated systems genomic and functional biology study
Authors
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WIPI1 may represent a target in right ventricular failure; animal data leave open clinical translation.
WIPI1 regulates mitochondrial oxidative signaling and non-canonical autophagy in cardiac myocytes, making it a potential target for RV-directed heart failure therapy.
Tzimas et al. (2019) studied this question.
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