Case series reveals dramatic LDL cholesterol elevation in individuals on ketogenic diets, indicating potential genetic susceptibility to lipid dysregulation.
High-fat, low carb dieting, also known as the "ketogenic diet," has increased in popularity as a rapid weight-loss tool. Previous studies describe a modest elevation in cholesterol in the average keto-diet participant without specific cardiovascular impact. We hypothesize that patients with a genetic predisposition to cholesterol metabolism dysregulation may have a disproportionate elevation in cholesterol in response to ketogenic dieting.
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Schmidt et al. (2023) studied this question.
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