What question did this study set out to answer?

The review aims to summarize evidence on puberty induction for girls with primary amenorrhea and outline future research directions.

April 4, 2026Endocrine ConnectionsOpen Access

Induction of Puberty in Hypogonadal Forms of Primary Amenorrhea: Current Evidence and Future Perspectives

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This review highlights puberty induction outcomes in girls with primary amenorrhea, suggesting tailored interventions for optimal health.

The review aims to summarize evidence on puberty induction for girls with primary amenorrhea and outline future research directions.
Comprehensive overview of current clinical practices in puberty induction.
Analysis of the role of oestrogen and progesterone therapies.
Review of existing data from Turner syndrome cohorts and observational studies.
Identification of areas needing further research, especially in bone metabolism and psychosocial aspects.
Oestrogen therapy is essential for achieving secondary sexual characteristics and proper uterine development.
Introducing progesterone too early can hinder development and should be individualized.
The need for patient-centered care is emphasized to optimize treatment outcomes.
Future research should focus on refining protocols based on individual characteristics.

Profka et al. (2026) studied this question.

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