Cross-sectional study shows systemic inflammation index relates to abnormal PTH levels in hemodialysis patients, suggesting potential assessment utility.
Hemodialysis patients with PTH levels below or above the recommended target range demonstrated elevated inflammatory markers (CRP and ferritin) and higher SII/NLR values, indicating a state of increased systemic inflammation. The SII and NLR were independent predictors of out-of-range PTH levels. These easily obtained indices may be useful for assessing inflammation in HD patients with altered mineral metabolism. Further research is warranted to determine whether addressing inflammation can modulate PTH levels or improve outcomes in this population.
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Çağlayan et al. (2026) studied this question.
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