What question did this study set out to answer?

This research aims to delineate the progression of kidney complications in sickle cell disease and their implications for patient management.

April 4, 2026

Natural History of Chronic Kidney Disease in Sickle Cell Disease

Key Points

This research aims to delineate the progression of kidney complications in sickle cell disease and their implications for patient management.
Reviewed existing data on nephropathy in sickle cell disease
Evaluated stages of kidney function from glomerular hyperfiltration to kidney failure
Analyzed the relationship between nephropathy and patient mortality
Initial glomerular hyperfiltration often occurs without significant protein loss (albuminuria)
Progression from hyperfiltration to severe albuminuria is observed
Decline in kidney function typically leads to increased mortality risk

Abstract

ABSTRACT Kidney complications, referred to as nephropathy, develop early in sickle cell disease (SCD). In addition to its known morbidity, abundant data show that chronic kidney disease (CKD) is associated with an increased mortality risk in SCD. Increasing evidence suggests that the natural history of SCD nephropathy is progressive. Initial glomerular hyperfiltration without albuminuria appears to precede increasingly severe albuminuria, kidney function decline, and eventual kidney failure. Based on the current understanding of the natural history of SCD nephropathy, intervention before the development of overt kidney disease may prevent albuminuria and CKD progression and perhaps decrease mortality.

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Cite This Study

Kenneth I. Ataga (Thu,) studied this question.

synapsesocial.com/papers/69d0af36659487ece0fa5124 https://doi.org/https://doi.org/10.1002/ajh.70300

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