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April 2, 2026Cancer Epidemiology Biomarkers & Prevention

Allostatic load, multimorbidity, and overall and cancer-specific survival among older adults in the United States

Jessica van Onselen MACI WINN Ainhoa Gómez-Lumbreras Claire Dunlap Roma Bhatia Sumati Gupta Jessica N. Cohan Sheetal Hardikar

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Key Points

The study aims to explore the relationship between allostatic load and multimorbidity on survival rates in older cancer survivors.
Assess allostatic load in older adults
Examine multimorbidity patterns
Analyze survival outcomes including overall and cancer-specific survival
Identified high-risk groups among older cancer survivors
Link between increased allostatic load and reduced survival rates
Noted significant impact of multimorbidity on cancer survival

Implication

This analysis assesses allostatic load and multimorbidity effects on cancer survival in older adults, highlighting health risks.

Abstract

Assessing AL, and multimorbidity could help identify high-risk older cancer survivors, and inform survivorship care.

Discussion

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Cite This Study

Onselen et al. (2026) studied this question.

synapsesocial.com/papers/69d0af83659487ece0fa581f https://doi.org/10.1158/1055-9965.epi-25-1994

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Keep reading

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Allostatic Load and Depression Symptoms in Cancer Survivorscross-sectional · 2023 · 13 citations
2A systematic review and empiric examination of the conceptual and analytic overlap between allostatic load and multimorbiditysystematic_review · 2026
3Association of allostatic load with overall survival in epithelial ovarian cancer2024 · 7 citations
4Abstract 6123: Validating cancer modulated allostatic load as a composite biomarker for mortality in patients with cancer2024
5Allostatic Load and Racial and Rural Disparities in Breast Cancer Survival2025 · 9 citations

More related papers

Allostatic load associated with all-cause and cause-specific mortality: a large prospective cohort study2026
Allostatic Load as a Measure of Cumulative Physiological Stress in Cancer: Implications for Prehabilitation in Head and Neck Cancers—A Narrative Review2026
Abstract A116: Pre-diagnostic allostatic load is associated with mortality in adults diagnosed with incident colorectal cancer2025

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